I’m running 285/50R20 on my 07 S/C. There’s a small amount of rubbing in various places but nothing serious. I have the suspension set about 35mm higher than standard. This helps with rubbing in the rear left tire when loaded in access mode. The rear right rubs on the fuel filler bulge which can be avoided with a zip tie to pull the inner liner forward. Lastly the front left rubs at full right lock. Just enough to clean off the dirt.